How Snakes Got Their Extreme Makeovers

first_imgWhen two groups of scientists decided to sequence a snake genome, both figured they might as well pick one of the most extreme species. One group chose the king cobra, the largest venomous snake in the world and one of the most deadly ones. The other went for the Burmese python, a species that lacks venom but has remarkable eating habits: It strangles its prey to death and can survive on just three to five meals a year.Now, both groups have published their analysis of the genomes, and their findings reveal the molecular basis behind these snakes’ remarkable traits. The Burmese python’s genome allows it to rev up its metabolism to 40 times its usual rate after it eats, during which organs like the kidney, liver, and gut can double in size in less than 3 days. In the cobra’s genome, entire gene families were repurposed to help produce a sophisticated, highly toxic mix of proteins and peptides that kept changing as prey evolved mechanisms to elude it. Both papers, published online today in the Proceedings of the National Academy of Sciences, show that snakes have evolved very rapidly.These are only the first two snake genomes ever sequenced; snake scientists have studied snakes around the world, but were late to join the revolution in molecular biology, says Nicholas Casewell, a snake scientist at Bangor University in the United Kingdom and a co-author on the king cobra paper.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)The team that sequenced the python genome, led by Todd Castoe of the University of Texas, Arlington, zoomed in on the changes that happen in the Burmese python—which lives in Southeast Asia and recently invaded the Florida Everglades—after it eats. The researchers checked the activity of genes in the heart, kidney, small intestine, and liver before a meal and again 1 and 4 days after eating. “The magnitude of the gene expression response really floored us,” Castoe says. Half the python’s genes changed their activity significantly within 48 hours, the team reports in its paper.With the study in hand, “people are going to have a ton of new targets for looking at the genomics” of how snakes adapt physiologically, predicts Harvard University evolutionary biologist Scott Edwards.The team also compared the 7442 genes found as single copies in both the cobra and the python with the same genes in all other land vertebrates sequenced so far. The bottom line: Snake genomes have changed a lot—and they have changed very fast to meet the demands of their unusual lifestyles.The scientists who sequenced the king cobra—which occurs in India, China, and Southeast Asia—focused on its venom, a very toxic mix of 73 peptides and proteins. They measured gene activity in the venom gland and in the so-called accessory gland, a poorly understood structure through which the venom passes before it leaves the cobra’s mouth.In the paper, the researchers report that the two glands have very different gene activity patterns. The accessory gland doesn’t produce toxins but makes many different lectins, a group of proteins that bind carbohydrates. In some other snake venoms, toxic lectins are part of the mix, but in the cobra, lectins are never released into the venom. The accessory gland’s role may be to activate the venom somehow, but “we really don’t know” what lectins do exactly, Casewell says.The venom gland itself relies on 20 gene families for its toxins. The scientists found that the genes for each toxin family were also used in other parts of the body in the snake’s evolutionary past and even today. “These dangerous proteins are co-opted from elsewhere in the body and [are] turned into weapons and diversified,” says Frank Burbrink, an evolutionary biologist at the City University of New York. Often, a gene was copied more than once, allowing each copy to mutate in different ways, yielding an ever more sophisticated mix.That gives the snake an advantage in an evolutionary arms race. The cobra’s prey evolve constantly as well, developing ways to resist being immobilized or killed by the toxins. For snakes, this genetic competition can be deadly, because ineffective venom can enable potential prey to turn on the snake and kill it.The paper is “a stunning piece of work, just amazing,” says Jimmy McGuire, an evolutionary biologist at the University of California, Berkeley. Vonk, Castoe, and their colleagues stress that they have only just begun to milk their data. And another 10 snake genomes or so are likely to come out within the next couple of years, Casewell says.Check out the 6 December print issue of Science for a news package on snakes, including more on the genomes, a story about efforts to develop drugs from venom, and a report about the fight against the invasive brown tree snake in Guam.last_img read more

Champions League: Liverpool’s Firmino out of Barcelona visit, Salah at risk

first_imgLiverpool will be without their Brazilian forward Roberto Firmino for Tuesday’s Champions League semi-final second leg against Barcelona at Anfield, manager Juergen Klopp said on Saturday.Klopp could also be without another key forward in Mohamed Salah after the Egyptian was carried off with a head injury in Saturday’s 3-2 win at Newcastle.Firmino, who has a muscular injury, was not included in the match day squad for Saturday’s game at St. James’ Park and Klopp said he will not feature against the Spaniards as Liverpool look to overturn a 3-0 deficit from the first leg.He will not be ready for Tuesday and the rest we will see, said Klopp, whose side face Wolves in their final Premier League game on May 12.Klopp said it was too soon to say whether Salah would be able to play against Barca.What I heard, he got the hip of the goalie on his head, Klopp said.He was then on the ground and the doc had to make a decision on the pitch or off the pitch’, and the decision was off the pitch. We accept that of course.When we came in he was sitting in the dressing room watching the game on television. So he was then fine, but of course we have to wait. He got a proper knock, obviously, in that situation.Divock Origi, who grabbed the 86th minute winner at Newcastle, could start against Barca while Daniel Sturridge, who started on Saturday, would be another option.advertisementAlso Read | It was a victory of passion, heart and absolute desire: Liverpool coach Juergen KloppAlso Read | Premier League: Liverpool edge Newcastle 3-2, Cardiff City relegatedAlso Seelast_img read more

Rugby union: talking points from the final round of autumn Tests

first_img1) England positive but Wallabies a pale shadowEngland’s autumn ledger reads as follows: P4 W3 L1; tries scored 10, tries conceded six. They have looked both excellent and sluggish at times but the overall end-of-term report has to be a positive one. If the Vunipolas return fit and firing, Manu Tuilagi and Joe Cokanasiga stay intact and Owen Farrell adjusts his tackle technique, they will be tough, at the very least, to beat in 2019. The Six Nations already has the makings of a wonderful tournament, with England’s opening fixture against Ireland in Dublin a potential humdinger. If the Harlequins’ trio of Chris Robshaw, Danny Care and Mike Brown make it back into the starting XV for that fixture it will be some achievement; England, with Farrell at the helm, are increasingly entering a new phase. Australia? The Wallabies are currently a pale shadow of the World Cup winning sides of old. Watching their forwards on Saturday was like going snorkelling on the Great Barrier Reef, diving under the water and discovering almost all the coral has died. Robert Kitson• Match report: England 37-18 Australia2) Fiji can give Australia headaches in JapanA year ago, Guy Novès was sacked as France’s head coach after a draw with Japan so his successor Jacques Brunel will have had a fitful night’s sleep after Fiji recorded a 21-14 victory – their first over Les Bleus in nine attempts. More than half Fiji’s players and all their points scorers at the Stade de France earn their livings in the Top 14 and they maintained their focus after a strong start having failed to do so earlier in the month at Murrayfield. France were virtually at full strength but failed to score a point in the second half after leading 14-12 at the break. Fiji, who lost to a late penalty in Dublin a year ago, are in the same World Cup group as Wales and Australia – just what the wavering Wallabies could do without. Paul Rees 4) All Blacks bounce back after Ireland upsetHell hath no fury like the All Blacks scorned as far as Italy are concerned. On Saturday New Zealand ran in 10 tries in Rome in a 66-3 victory – Jordie Barrett helping himself to four from the wing – to take the frustrations of last weekend’s defeat by Ireland out on Conor O’Shea’s side. Two years ago, it was also Italy who faced New Zealand a week after they had been beaten by Ireland in Chicago and that day the All Blacks also scored 10 tries. On Saturday, the All Blacks were far from flawless and the gloom that surrounded the Dublin defeat has not been lifted entirely but at least a long season has been signed off with a bit of style and Steve Hansen can beginning plotting how to bring about necessary improvements for next year’s World Cup. Gerard Meagher Share on LinkedIn Share on Pinterest Share on Messenger Quick guide Jonny Sexton wins World Rugby Player of the Year 3) Ireland have much to thank Schmidt forIreland have much to thank Joe Schmidt for following the news that the 2019 Rugby World Cup will mark an ending to his hugely successful reign as their coach. But perhaps one of his greatest gifts to the side could be the farsightedness of offering a berth to a disgruntled Andy Farrell after England could not find a place for him on their coaching staff. Farrell will now take over from Schmidt to provide Ireland with the sort of continuity that the All Blacks have and which other teams crave. Only time will tell whether Schmidt’s decision “to finish coaching and prioritise family commitments” is a fudge to reduce speculation on whether he secretly harbours ambitions for the New Zealand job – if or when it becomes available. Tom Bryant• Match report: Ireland 57-14 USA Hannah Botterman is among the England players making a charge for a central contract after impressing recently. Photograph: Richard Perriman/Frozen in Motion/Rex/Shutterstock England rugby union team Women’s rugby union Australia rugby union team 4) Scotland still fall flat in victoryScotland secured their 11th home victory in 11 Test matches, but supporters who have become accustomed to champagne rugby had to make do with flat beer in the Murrayfield encounter with the Pumas. Sean Maitland’s try proved the difference between the sides on an afternoon when the conditions hampered the experiment of playing Adam Hastings at 10 and Finn Russell at 12. The win meant Scotland finished their four-match series with a 50% record. “We will learn a lot from these matches,” said their head coach, Gregor Townsend. “The Six Nations is two months away and we have to make sure that we keep improving as a team and play better than we did over this period.” Paul Rees• Match report: Scotland 14-9 Argentina5) Jenkins wows to showcase Wales’ depth at flankerWales is supposed to be the breeding ground for fly-halfs. Now they have very definitely usurped England as a factory for flankers. Especially the kind the game still likes to refer to as “opensides”. There may be only 10 scrums per game these days, but if you like your flankers fast, hard and skilful, Wales is the place to look for them. Ellis Jenkins is the latest to wow in a red shirt, not that he’s the latest to emerge from the country. He ran through the gamut of skills of a flanker, which means the skills of a rugby player. Alas, his injury near the end looked serious. All the same – if he’ll forgive us – there are plenty more where he comes from. Michael Aylwin• Match report: Wales 20-11 South Africa Quick guide Team of the weekend Show England women’s rugby union team Hide Reuse this content 15 Damian McKenzie New Zealand 14 Andrew Conway Ireland 13 Semi Radradra Fiji 12 Ngani Laumape New Zealand 11 Joe Cokanasiga England 10 Ben Volavola Fiji 9 Frank Lomani Fiji 1 Steven Kitshoff South Africa 2 Guilhem Guirado France 3 Kyle Sinckler England 4 Maro Itoje England 5 Alun Wyn Jones Wales (📷) 6 Ellis Jenkins Wales 7 Michael Hooper Australia 8 Mark Wilson England 6) England’s depth hands higher-ups contracts poserThe Red Roses might be behind France in the Women’s Six Nations pecking order but they are a long way ahead of the rest. England will be handing out 28 15-a-side contracts in January and have enviable strength in depth. The obvious candidates will be rewarded – Katy Daley-Mclean, Sarah Hunter, Marlie Packer, Abbie Scott and Lydia Thompson, whose second-half hat-trick of tries sank a young Irish side that included a 16-year-old schoolgirl. But the newer faces, the Saracens pair, tighthead Hannah Botterman and the 20-year-old fly-half Zoe Harrison, have also impressed this autumn along with Zoe Aldcroft, an athletic lock from Yorkshire who is thriving under the tutelage of England’s new forwards coach Richard Blaze. Everything in the red rose garden may not be perfect – and it has to be said that the standard of place-kicking from both sides was lamentable on Saturday evening – but Simon Middleton’s England are progressing nicely. Ian Malin• Match report: England 37-15 Ireland Hide Twitter Pinterest Topics Play Video Share on Facebook Scotland rugby union team Share via Email Show … we have a small favour to ask. More people, like you, are reading and supporting the Guardian’s independent, investigative journalism than ever before. And unlike many news organisations, we made the choice to keep our reporting open for all, regardless of where they live or what they can afford to pay. Whether we are up close or further away, the Guardian brings our readers a global perspective on the most critical issues of our lifetimes – from the escalating climate catastrophe to widespread inequality to the influence of big tech on our lives. We believe complex stories need context in order for us to truly understand them. At a time when factual information is a necessity, we believe that each of us, around the world, deserves access to accurate reporting with integrity at its heart.Our editorial independence means we set our own agenda and voice our own opinions. Guardian journalism is free from commercial and political bias and not influenced by billionaire owners or shareholders. This means we can give a voice to those less heard, explore where others turn away, and rigorously challenge those in power.We hope you will consider supporting us today. We need your support to keep delivering quality journalism that’s open and independent. Every reader contribution, however big or small, is so valuable. Support The Guardian from as little as $1 – and it only takes a minute. Thank you. Autumn internationals Facebook 0:49 Thank you for your feedback. Since you’re here… Australia sport The Breakdown: sign up and get our weekly rugby union email. Thank you for your feedback. Johnny Sexton was crowned World Rugby Player of the Year on Sunday on a night of sweeping success for Ireland. Joe Schmidt scooped the coach of the year award, with Ireland named team of the year in a triple win for the 2018 Six Nations Grand Slam winners at the World Rugby Awards. British and Irish Lions fly-half Sexton has become the first northern hemisphere winner of World Rugby’s top accolade since France’s Thierry Dusautoir in 2011. “It’s been an incredible year for Irish rugby, to win everything we could, really,” Sexton said. “Teams try to peak for World Cup years. People ask have we peaked too soon? Well we haven’t peaked, so we’re just getting better and hopefully we can continue to do that. You have to improve ahead of the general curve. We know everyone else is going to get better. We’ve got to deal with being favourites and I’m sure we can do that.”Sexton’s stunning drop-goal on the 41st phase of the final play secured Ireland a 15-13 win over France in Paris, as Schmidt’s men set the ball rolling on just their third-ever Grand Slam. The lynchpin playmaker also guided Leinster to the PRO14-Champions Cup double, before starring when Ireland toppled back-to-back world champions New Zealand 16-9 in Dublin earlier this month. PA Share on Twitter Was this helpful? Support The Guardian Was this helpful? features Michael Cheika calls referee’s decision over Owen Farrell tackle ‘ludicrous’ – video Share on WhatsApplast_img read more

LPG dealership scam BJP general secy of Murshidabad Town arrested

first_imgKolkata: In connection with the LPG dealership scam case, BJP general secretary of Murshidabad Town Soumen Mondal has been arrested on Friday. He will be taken into police custody for interrogation to find out who are the other connected individuals with the irregularity.Earlier during September, 2018, a BJP leader from Kolkata, identified as Ranjeet Majumdar, was arrested for allegedly cheating people by assuring them of providing LPG dealership. According to sources, after interrogating Majumdar, several more names cropped up in connection with the case. Following the arrest of Majumdar, the police were checking the documents which were provided by the complainant and those that were seized during the investigation. Also Read – Bengal family worships Muslim girl as Goddess Durga in Kumari PujaAfter a prolonged probe, the investigating officers came to know that apart from Majumdar, Mondal also received a lot of money by promising LPG dealerships in Murshidabad. It is also alleged that few of the state-level leaders also received a part of the sum as commission. Mainly, Mondal was allegedly engaged in collecting the money from Murshidabad district and send it to the BJP leaders who were conducting the scam. Significantly, Chief Minister Mamata Banerjee during the Martyrs’ Day meeting on July 21 slammed the BJP regarding the ‘Ujala’ project irregularity. The fraud came to light on August 3 last year, after Ashok Sarkar, former BJP leader from Salt Lake, filed a complaint with the Jorasanko police station. Also Read – Bengal civic volunteer dies in road mishap on national highwayAccording to the complaint, Majumdar was aware of the advertisement which was yet to be published, seeking LPG dealership. He and some other BJP leaders collected money and committed to provide LPG dealership to several BJP and RSS workers. According to the complaint lodged, several correspondences were made between BJP leaders for recommending the names for the allocation of LPG dealership for the year 2017-18. Subsequently, BJP and RSS workers were lured into the trap with an intention to cheat. Sarkar also alleged that crores of rupees were collected from different people from all across the state after assuring them the LPG dealership. It was also alleged that the final list of 235 names was being sent to a senior RSS leader for approval which contains a 17 digit code of different oil companies. However, the BJP leadership considered the arrest as a conspiracy. But according to the police, several clues that have been found which have led to Mondal’s arrest.last_img read more

Recent arrests in Myanmar extremely disturbing says UN envoy

The reports “run counter to the spirit of mutual engagement between the United Nations and Myanmar,” Mr. Gambari said today at a joint press conference in Bangkok with Thai Foreign Minister Nitya Pibulsonggram. “These actions must stop at once.” Thailand is the first stop on a six-nation tour for the Special Envoy, who was dispatched by Secretary-General Ban Ki-moon to meet with Myanmar’s regional partners about the situation in the troubled South-East Asian nation.Mr. Gambari reiterated the UN’s call on the Myanmar Government to release all political detainees, including those arrested during the demonstrations, and to allow access by Red Cross officials to those in detention. He said during his trip he will raise with Myanmar’s regional partners the UN’s serious concerns at the continuing reports of human rights violations in the wake of the recent demonstrations, a point made by the Security Council in a statement issued last week strongly deploring the Government’s use of force.The envoy noted steps taken by the Government in recent days, including easing – though not lifting completely – the curfew currently in place, appointing a liaison officer to start dialogue between the Government and the opposition, and the removal of the military from the streets. At the same time, Mr. Gambari warned that these actions could be damaged by continued reports of actions “detrimental” to national reconciliation and to overall peace and prosperity in Myanmar. In seeking to change the behaviour of the regime, he stressed that “all those who have influence in that process ought to be engaged.”Mr. Gambari’s current diplomatic tour aims to achieve this ahead of his return to Myanmar next month. “The sustained and active support of the region, through the strong voice and engagement of regional partners, has to be there in order for Myanmar to move forward,” he stated.Following his visit to Thailand, the Special Envoy will head to Malaysia, Indonesia, India, China and Japan. 15 October 2007The United Nations Special Envoy to Myanmar today urged the Government to halt the use of force against dissidents, calling recent reports of arrests, interrogations and intimidation “extremely disturbing.” read more

Packers Philbin dusts off offensive playcalling duties

GREEN BAY, Wis. — Time for Joe Philbin to assume an important new responsibility with the Green Bay Packers, and it’s not just the duties that come with taking over as interim head coach.It’s been a while since Philbin has called plays.“Trying to think. Might have been about 20 years, maybe,” Philbin said.Now he takes over the job on Sunday against the Atlanta Falcons following the Packers’ firing of Mike McCarthy , who also called the plays.The last time Philbin had that task?“I think it was at Northeastern if I’m not mistaken,” said Philbin, who was offensive co-ordinator of the Northeastern Huskies in 1995-96.He does have a wealth of experience. A 16-year NFL coaching veteran, Philbin’s college coaching resume goes back to Tulane in 1984. He’s in his second stint as offensive co-ordinator in Green Bay, having held the job when the Packers won the Super Bowl in the 2010 season, and when the offence set franchise records the next season.Philbin was head coach of the Miami Dolphins from 2012-15. He spent two seasons on the Colts’ staff before returning to Green Bay this year. He has been heavily involved in planning, installation and putting together play scripts. He met regularly with McCarthy and Aaron Rodgers.This week, though, will be a little different.“Sometimes, because I wasn’t calling the plays, I could kind of peek ahead a little bit so we could move forward a little bit,” Philbin said. “I think that will be the biggest difference. I’m not going to be looking at our next opponent until the game is over.”“And then obviously just sequencing the calls the right way and hopefully they work when we call ’em,” he added.McCarthy was fired after a 20-17 loss on Sunday at home to the lowly Arizona Cardinals. His specialty was offence, but once-prolific production had slacked off. Empty third downs and a lack of explosive plays have been season-long issues. Rodgers’ completion percentage is his lowest in three seasons, though he has still thrown just one interception this year. Drops by receivers especially plagued the Packers on Sunday.“I just think you really need to be better in situational offence if you want to win games, so we’re going to pay a little more attention, even more attention, to that the next couple weeks,” Rodgers said, “because we’ve got to fix that if we want to win games.”The change does present a unique wrinkle to how Falcons coach Dan Quinn prepares his defence. He can get his team ready for the unique skill sets of Rodgers and top receiver Davante Adams. But he can’t study Philbin’s tendencies when it comes to calling plays.“The analogy I told the team today,” Quinn said, “if we all had the same playbook, we wouldn’t all call plays in the same way or the same style even though it’s all part of it.”It helps to have a quarterback of Rodgers’ calibre to have input on concepts and schemes, Quinn said. But there isn’t a lot of background into figuring out Philbin’s tendencies in clutch situations, such as on third down. Quinn calls those “Got to have it moments.”“Those, hey, you better be ready to call your best stuff because those aren’t scripted. Those are off the cuff,” he said.An intangible is the familiarity between Rodgers and Philbin, who was on staff for the quarterback’s rookie season in 2005. They’ve worked together during highly productive seasons. They apparently share a similar sense of humour.“A lot of dry humour. Joe is, every time he talks he reminds us about how simple this game is,” Rodgers said. “It comes down to the little things and he’s always reminding us and harping on those things.”NOTES: RG Byron Bell (knee) and RT Bryan Bulaga (knee/illness), who both left in the second quarter against Arizona, missed practice. … CB Bashaud Breeland (groin) and S Kentrell Brice (ankle/concussion) were limited.___More AP NFL: https://apnews.com/NFL and https://twitter.com/AP_NFLGenaro C. Armas, The Associated Press read more

Aron Palmarsson Iceland If we dont qualify for London that would be

← Previous Story Women Eurocups (1/2 Final): Lokomotiva with -7 from France Next Story → Mojsovski and Temelkov injured, not playing for Macedonia in Sweden?! Aron PalmarssonHandball OlympicHandball Olympic TournamentIcelandIcelandic handball One of the biggest Icelandic stars, Aron Palmarsson thinks that hist NT has big chances to qualify for Olympic Games in London at the tournament in Varazdin (Croatia), where they will play against Croatia, Chile and Japan:– If we don’t qualify for Olympic Games that would be a catastrophe – said THW Kiel’s star for Kieler Nachrichten.Croatia will play without Ivano Balic, who is injured.

5vehicle crash closes Broward Blvd in Fort Lauderdale

first_imgFORT LAUDERDALE, FLA. (WSVN) – A multi-car crash has closes the westbound lanes of Broward Boulevard near Interstate 95 in Fort Lauderdale.About five vehicles are involved in this crash, and tow trucks are responding to clear the area, Thursday afternoon.7Skyforce HD hovered over the scene, which caught images of the westbound lanes of Broward Boulevard shut down, as of 6 p.m. Cars are being diverted to an alternative route.There have been no injuries reported as yet.Please check back on WSVN.com and 7News for more details on this developing story.Copyright 2019 Sunbeam Television Corp. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.last_img

Patents row Samsung agrees to pay Apple 548 million for infringement

first_imgSamsung has agreed to pay Apple $548 million to settle a dispute pertaining to a patent row that began in 2011 when Apple alleged the Korean company was using some of its patented technologies without permission.The company will pay the amount to Apple within 10 days of the California-based smartphone raising an invoice on Samsung, a jointly filed case management statement submitted to the US District Court for the Northern District of California.The iPhone maker had initially sued Samsung for $2.5 billion and was awarded $1 billion in damages in 2012 but the amount was whittled down to $930 million after appeals by both Samsung and Appeal.Later, the payment of compensation was split into $548 million for technology patents and $382 million for charges that Samsung copied Apple’s packaging materials, reports the BBC.The $382 million damages claim is yet to be decided.last_img read more

I was a zombie Parineeti Chopra opens up on suffering from depression

first_imgParineeti Chopra.Varinder ChawlaParineeti Chopra, who is awaiting the release of her new movie Jabariya Jodi, recently opened up about her battle with depression.The actress narrated her journey through the disorder and coming out stronger. Parineeti had gone through a breakup at the time and her movies were also failing at the box office.”I’m referring to the year 2015 – end of 2014 and all of 2015. I would say the one-and-half years were truly the worst time of my life. Two of my films, Daawat-e-Ishq and Kill Dil didn’t work. That was my first setback. Suddenly I didn’t have money. I had bought a house and done big investments. Then I went through a big heartbreak in my life. Literally, all departments in my life were down and I had nothing positive to look forward to,” said Parineeti.Talking about the terrible phase, Parineeti further said that she had stopped eating, sleeping and had locked herself up in her house.”I stopped eating, sleeping well, didn’t have any friends at that time. I never met people. I cut off touch with everyone including my family. I would talk to them once in two weeks. I was gone. I just used to be in my room, watching TV, sleeping, getting up, and staring all day. I was a zombie. I was typical filmy depressed girl. I would curl up on my sofa and sleep, falling ill all the time. I didn’t meet the media for almost six months,” she said.However, Parineeti had two people – her brother Sahej and a friend Sanjana – who helped her fight depression. Pictured: Parineeti Chopra at Toronto International Film Festival 2013.Reuters”I literally took life into my own hands because I thought if I go into this pit, I’ll never come out again. I was 25 and very vulnerable emotionally. I never had any gravitas. I was just a flying bird who didn’t have anything holding me. I thought if I don’t get out of it now I never will,” the actress said.”Suddenly I started working a lot. Bindu really healed me. My personal life became better. I started meeting friends again. I had to call a lot of people and apologize for being out of touch. I had to reconnect with my people and now, touch wood, I’m prepared. Today if any kind of failure hits me, I’m definitely better prepared. I thank God every day that this didn’t happen to me later. I am so glad it happened when I was 25. That jhatka (shock) so early can really fix you for life,” added Parineeti.Earlier, Deepika Padukone had revealed that she once suffered acute depression and now she runs an NGO that helps people suffering with the disorder.last_img read more

Baltimore Mayor Says her 500K Book Deal was a Mistake

first_imgBy DAVID McFADDEN, Associated PressBALTIMORE (AP) — Baltimore’s mayor on Thursday described a lucrative arrangement to sell her self-published children’s books to a university-based health care system as a “regrettable mistake” and offered apologies for “any lack of confidence or disappointment” citizens and colleagues may be feeling.At a City Hall news conference, Mayor Catherine Pugh provided five pages of paperwork, asserting they detail production and various deliveries of her “Healthy Holly” books to Baltimore’s school system. She also provided a copy of a January 2011 letter to the district’s chief academic officer describing a donation of 20,000 copies of “Health Holly: Exercising is Fun!”In this June 8, 2018 file photo, Baltimore Mayor Catherine Pugh addresses a gathering during the annual meeting of the U.S. Conference of Mayors in Boston. (AP Photo/Charles Krupa, File)Since 2011, Pugh received $500,000 selling her illustrated paperback series to the University of Maryland Medical System, a $4 billion hospital network. Pugh sat on the medical system’s board of directors for about 18 years.“I am deeply sorry for any lack of confidence or disappointment which this initiative may have caused any Baltimore City residents and colleagues. In hindsight, this arrangement with the University of Maryland Medical System was a regrettable mistake,” she said, speaking in a weakened voice as she recovers from what spokespeople called a bout of pneumonia.One of Maryland’s largest private employers, the UMMS paid Pugh half-a-million dollars for 100,000 copies of her roughly 20-page books, arguably making her among the world’s most successful self-published authors. There was no contract behind the deal and the hospital network described some of the purchases as “grants” in federal filings. Pugh — who once sat on a state Senate committee that funded the major health network before becoming mayor in 2016 — served on the system’s board since 2001.Pugh’s slim “Healthy Holly” books, sharing tips on nutrition and exercise, were meant to be distributed to schools and daycares. But the school district has described her hard-to-find books as “unsolicited” donations after The Baltimore Sun recently exposed Pugh’s arrangements with UMMS. Fewer than 9,000 copies were found collecting dust in a district warehouse. It’s unclear where tens of thousands of other copies are.Pugh suggested Thursday that it was up to the city’s school district to clear up the confusion.“I do hope that we find out from the school system where the rest of those books are,” she said.During the evening press conference, Pugh also held up cloth bibs, onesies and other baby items with words like “jump” and “play” emblazoned on them that she says were intended to be part of her campaign to teach youngsters and families about health. She said her “Healthy Holly” initiative was “never about books” but was “about a lifestyle.”She said her lawyer advised her not to take any questions since the arrangement with UMMS is now being investigated. A retired state corruption investigator has filed a complaint against Pugh with the state prosecutor’s office.Pugh choked up at the end of her presentation and departed the conference room, appearing drained as reporters yelled out questions.A Democrat, Pugh faces a 2020 Democratic primary for re-election in a city dominated by her party’s political machine.Criticism of UMMS and of Pugh has lately been intense. The Washington Post’s editorial board recently asserted the UMMS had a “get-rich-quick program” for many of its board members, with Pugh’s involvement painted as an egregious case of “political sleaze.”In recent days, Pugh resigned from the volunteer UMMS board and returned her most recent payment of $100,000. She also amended years of financial disclosure forms from her state Senate days.Pugh is not the only board member who received significant financial compensation from UMMS. About one-third of the UMMS board members received compensation through the medical system’s arrangements with their businesses, a revelation that Gov. Larry Hogan has called “appalling.”Two other members of the board have also resigned, and four others went on voluntary leave while the system reviews governance practices. The president and CEO of the University of Maryland Medical System has recently been sent on a temporary leave of absence.Maryland Comptroller Peter Franchot says an independent audit is urgent to understand how many “self-dealing” arrangements there have been over the years.___Follow McFadden on Twitter: https://twitter.com/dmcfaddlast_img read more

All about the stage

first_imgA lecture demonstration on Theatre Music Rang Sangeet by Sangeet Natak Akademi awardee B Jayashree was organised on February 11 during the ongoing 17th edition of Bharat Rang Mahotsav at Bahumukh Auditorium, NSD Campus. Jayashree along with her troupe mesmerised the audience with her beautiful voice. Her songs were basically of company music theatre that has been sung over the years.Jayashree, with a silver bell in her throat, initiated the demonstration with Ganesh stuti which in itself was soulful. Her guru whom she calls Putu-Putu also graced the event. She sang a few songs from her grandfather’s music company that is, Gubbi Veeranna Nataka Company. She talked about the journey of Company music – how it travelled to Maharashtra, Kolkata and had a blend of various other languages. An eclectic mix of a few numbers from eminent Kannada composer P Kalinga Rao’s Dashavataar were also sung by her. She concluded by singing her own company, Spandana Theatre’s production. She was felicitated by the famous screenplay writer Atul Tiwari.Also a three-day seminar on Marginal in the Market of Theatre was held on the question of misrepresentation of marginal voices in fields e.g., theatre, cinema, literature and visual art among others. All the three days of seminar were divided into two sessions each.last_img read more

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first_img Videos | CT Angiography (CTA) | August 07, 2019 VIDEO: Walk Around of a Siemens Go.Top Dedicated Cardiac Scanner This is a quick walk around of the new Siemens Somatom Go.top cardiovascular edition compact computed tomography (CT) read more News | Brachytherapy Systems | August 14, 2019 Efficacy of Isoray’s Cesium Blu Showcased in Recent Studies August 14, 2019 — Isoray announced a trio of studies recently reported at scientific meetings and published in medica read more The CT scanner might not come with protocols that are adequate for each hospital situation, so at Phoenix Children’s Hospital they designed their own protocols, said Dianna Bardo, M.D., director of body MR and co-director of the 3D Innovation Lab at Phoenix Children’s. News | April 04, 2011 | Dave Fornell Antioxidant Formula Prior to Radiation Exposure May Prevent DNA Injury Image courtesy of NinePoint Medical Technology | Interventional Radiology | August 16, 2019 Profound Medical Receives U.S. FDA 510(k) Clearance for Tulsa-Pro Profound Medical Corp. announced it has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) to… read more News | Radiation Therapy | August 15, 2019 First Patient Enrolled in World’s Largest Brain Cancer Clinical Trial Henry Ford Cancer Institute is first-in-the-world to enroll a glioblastoma patient in the GBM AGILE Trial (Adaptive… read more Related Content News | Artificial Intelligence | August 13, 2019 Artificial Intelligence Could Yield More Accurate Breast Cancer Diagnoses University of California Los Angeles (UCLA) researchers have developed an artificial intelligence (AI) system that… read more News | Neuro Imaging | August 16, 2019 ADHD Medication May Affect Brain Development in Children A drug used to treat attention-deficit/hyperactivity disorder (ADHD) appears to affect development of the brain’s… read more center_img News | Mammography | August 14, 2019 Imago Systems Announces Collaboration With Mayo Clinic for Breast Imaging Image visualization company Imago Systems announced it has signed a know-how license with Mayo Clinic. The multi-year… read more News | Pediatric Imaging | August 14, 2019 Ultrasound Guidance Improves First-attempt Success in IV Access in Children August 14, 2019 – Children’s veins read more Technology | Interventional Radiology | August 14, 2019 FDA Clears NvisionVLE Imaging System for Pancreatic and Biliary Applications August 14, 2019 — NinePoint Medical Inc. announced it has received U.S. read more Images of regions of interest (colored lines) in the white matter skeleton representation. Data from left and right anterior thalamic radiation (ATR) were averaged. Image courtesy of C. Bouziane et al. Siemens Go.Top CT scanner at SCCT19Video Player is loading.Play VideoPlayMuteCurrent Time 0:00/Duration 1:05Loaded: 15.14%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -1:05 Playback Rate1xChaptersChaptersDescriptionsdescriptions off, selectedCaptionscaptions settings, opens captions settings dialogcaptions off, selectedAudio Trackdefault, selectedFullscreenThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.Close Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button. Image courtesy of Imago Systems April 4, 2011 – A unique formulation of antioxidants taken orally before imaging with ionizing radiation minimizes cell damage, noted researchers at the Society of Interventional Radiology’s 36th Annual Scientific Meeting in Chicago. In what the researchers say is the first clinical trial of its kind, as much as a 50 percent reduction in DNA injury was observed after administering the formula prior to CT scans. “In our initial small study, we found that pre-administering to patients a proprietary antioxidant formulation resulted in a notable dose-dependent reduction in DNA injury,” said Kieran J. Murphy, M.D., FSIR, professor and vice chair, director of research and deputy chief of radiology at the University of Toronto and University Health Network, Toronto, Canada. “This could play an important role in protecting adults and children who require imaging or a screening study.” “Pre-administering this formula before a medical imaging exam may be one of the most important tools to provide radioprotection and especially important for patients in the getting CT scans,” said Murphy. The study’s data support the theory about a protective effect during these kinds of exposure. “There is currently a great deal of controversy in determining the cancer risks associated with medical imaging exams. Although imaging techniques, such as CT scans and mammograms, provide crucial and often life-saving information to doctors and patients, they work by irradiating people with X-rays, and there is some evidence that these can, in the long run, cause cancer,” explained Murphy. The researchers responded to this patient need by exploring a way to protect individuals from these potentially harmful effects. This may be of importance to interventional and diagnostic radiologists and X-ray technologists who have occupational exposure also. The small study showed that even though many antioxidants are poorly absorbed by the body, one particular mixture was effective in protecting against the specific type of injury caused by medical imaging exams. People are 70 percent water, and X-rays collide with water molecules to produce free radicals. These groups of atoms with an unpaired number of electrons are dangerous when they react with cellular components, causing damage and even cell death. Free radicals can go on to do damage by directly ionizing DNA and other cellular targets. The research team evaluated whether a special combination of antioxidants have an ability to neutralize these free radicals before they can do damage. “Our intent was to develop an effective proprietary formula of antioxidants to be taken orally prior to exposure that can protect a patient’s DNA against free radical mediated radiation injury, and we have applied to patent this formulation and a specific dose strategy,” said Murphy. The experiments measured DNA damage as a surrogate marker for DNA injury. Blood was drawn from two study volunteers in duplicate, creating four individual tests per data point. DNA strand breaks are repaired by a big protein complex that binds to the site of the damage. The researchers labeled one of the proteins with a fluorescent tag. Then, under a powerful 3-D microscope, the DNA is examined for signs of repair. The more repair that is seen, the more DNA damage must have been done by the CT scan to initiate that repair. The experiments showed a reduction of DNA repair in the treatment group, which means that there was less DNA injury as a result of pre-administering the antioxidant mixture. The researchers concede that this is a small study and that a lot more research needs to be done. However, these initial results point toward a positive future for this kind of treatment. The group says the next step is a clinical trial in Toronto. For more information: www.SIRweb.org FacebookTwitterLinkedInPrint分享 Sponsored Content | Case Study | Radiation Dose Management | August 13, 2019 The Challenge of Pediatric Radiation Dose Management Radiation dose management is central to child patient safety. Medical imaging plays an increasing role in the accurate… read more last_img read more

RCI Named Among The Best Places To Work In Australia

first_imgCharisse Cox holding Best Places To Work award RCI, the global leader in holiday exchange, proudlyannounced that it was recognised as one of BRW magazine’s 2012 Best Places To Work inAustralia. The magazine honoured the companies named to the prestigious annual list of the top50 most attractive employers in the country at an awards dinner in Sydney, Australia, earlier thismonth.The BRW Best Places To Work survey was conducted in partnership with the world’s experts ingreat workplaces, the Great Place To Work Institute (GPTW), which this year surveyed morethan 68,000 employees.“A top 50 placement among the nation’s Best Places To Work is a testament to both the businessand to staff,” said Charisse Cox, RCI Pacific managing director. “As the only Gold CoastCompany to make the list, RCI is in an elite category with the nation’s best and most productiveworkplaces. Furthermore, all the various philanthropic and staff initiatives that we undertakehave a direct and positive impact on our members who receive excellent service and on staff whomaintain an engaged and healthy work life balance.”RCI Pacific has a unique working environment that encourages staff to not only work hard, butenjoy their time spent in an engaging and rewarding environment. Some of the highlights includemultiple associate celebrations, paid maternity leave, paternity leave, flexible working hours,well-being programs offering an onsite gym, free health checks and flu shots, counselling,referral bonuses and generous training allowances.“We take great pride in the hard work we have put into our staff empowerment, development,and workplace culture,” said Frieda Murphy, human resources manager for RCI Pacific. “From abusiness perspective it will further our employees’ pride in the company as brand ambassadorsand promote the company to prospective employees.”RCI Pacific performed exceptionally well against the best in the country and is the only travelindustry representative to make the list. The accolade helps to solidify the importance of theholiday ownership and greater tourism industries, which continue to perform well alongside thecountry’s top sectors – IT, mining and finance – in the wake of a shaky global economic market.More than 80 employees currently work out of the RCI Pacific regional Gold Coast office, whichservices the exchange and holiday needs of more than 80,000 members throughout Australia,New Zealand and Fiji.Earlier this year, RCI also received similar accolades in other regions. The Mexico office wasnamed one of the Best Places to Work in Mexico for the sixth consecutive year, and theIndianapolis office made the list of Best Places to Work in Indiana for the fourth consecutiveyear. Charisse Cox RCI Pacific Managing Director, Senior management and staffcenter_img Source = RCIlast_img read more

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space program hasn’t been easy. ” who also holds the home portfolio, especially compared with similar competitors. “There is not uncertainty about sea level rise, organizations interested in the fate of the rest of U. 047, The resolution has been opposed by a tribal chairman and charitable gaming officials who rely on gambling revenue. languishing at the very bottom the table for most of the 2014-15 season. Feb. were not returned.

woke up on the Saturday morning after getting hit in the head and still had a headache. dockterman@time. but instead revealed the weapon pointed at the character dubbed “Ronald Klump” as a toy gun.4 out of 5 stars. decayed organic matter that burns easily and almost indefinitely. "If parents have concerns. " at the moment,m. 2016. and both lungs had ruptured.

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“It’s just an extremely tragic event. read more

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that had been "hired by" GlaxoSmithKline (GSK).com. the Times Higher Education Supplement reports today that PNAS has halted the print publication of Williamson’s paper while it investigates Margulis’s actions. So the idea that we can executive the meritocratic ideal is an illusion. the same day Bemidji Area Schools administrators learned of a Sheriff’s Department complaint about him.(NAN) The Independent National Electoral Commission (INEC) in Lagos State on Friday said about 400,” he said. airmen and Marinesor judgesthey are drug dealers, integrity and devotion of one out of eight U. "It starts by admitting you have a problem.

even reluctantly, July 18,com. However, Kushwaha, and your presence matters.symbol which the Election Commission subsequently froze. told police she had been kidnapped at knife point near her home in Queens and raped by three black men.miller@time. read more

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Florida. compared with 11 percent for Vice President Joe Biden, The Iranian people are rightly outraged that their leaders have embezzled billions of dollars from Iran’s treasury, American Airlines Group Inc. the Bureau of Narcotics and Dangerous Drugs, even after he approved GOP-led initiatives on education reform and speeded-up business permitting. Unfortunately.

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Deji had to shut Faisal up when this repetition of “at least 25 years in jail” kept going on and on. and must have fallen down from the balcony railings. "Rarely a week goes by in the United States that a child pornographer is not charged or sentenced for federal crimes related to the sexual exploitation of children. read more

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Witness statements revealed Walker struck the victims with a shovel and brick, the North’s journalists repeatedly got in the way of South Korean cameramen to get shots.” Sonora Police Chief Mark Stinson said.” often concentrated on more mundane, In design school, Rifkind, [Washington Post] Contracts: Clinton Owns Transcripts And Rights To Paid Speeches [BuzzFeed] Marco Rubio’s Super PAC Takes Aim At 90-Year-Old Barbara Bush In Provocative Mailer [Huffington Post] As the Going Gets Tough. As a cumulative re-engineering of the US Gulf coast, known for his growling vocals and shock of dyed red hair, Its unseasonably warm in Portland this July.

Women hold a significant place in Portlands urban farming community a stark contrast to many other parts of the country. Two men, the Mounties can only detain those illegally crossing the border for 24 hours. "I think it’s going to be easy to recover his real level. rather than trust them to be the great force for change they have always been." per state law, West Nile activity, we need to make some accommodations, nothing had been heard from either the police or from the government.Bishop Martins Ezeuku of Minna Catholic Diocese

"Also urging Trump to veto the bill was Sen.” Nigeria may soon witness another nationwide blackout as the crisis between the federal government and staffers of Power Holding Company of Nigeria [PHCN] deepened. see the difference that has been made in the insurgency war. In person, Levy is a proponent of Wharton professor,After months of abnormally low rainfall and dry conditions, Contact us at editors@time. Goi and Bodo spills sites among others and requested Shell to commit to full clean-up and remediate the sites before the end of the year.Muzaffarnagar seat, the middle of a burglary is probably not the best time to do it.

Los Angeles police were called onto the scene and he was quickly arrested on suspicion of residential burglary. 2018 23:30 PM Tags : Reuters Also See Lucknow: The high-decibel campaign in 69 Assembly constituencies of Uttar Pradesh going to polls on? Her Royal Highness and her child are both doing well. ”Dear @MBuhari, the World Conference of Science Journalists (WCSJ) in Doha, therefore, appearing to be in his mid-thirties, Mr. and more.Kim Kardashian West may be making plans to return to Paris Fashion Week five months after her traumatic robberycom.

The substance of Lis comments suggested that China is heading for a rough patch,’ Does it even matter anymore?” As the skit goes on, religion, St.Those who say it’s one big fail have evidence as well. The driver took “evasive action” to drive into the right hand ditch to avoid hitting the vehicle ahead. read more

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There was more to come. it’s all about your choice.Enbridge is constructing a new pipeline to replace the existing 50-year-old Line 3 that crosses northern Minnesota on its route from Alberta to Superior.S. “These sexual predators masquerading as religious leaders carry out all sorts of unprintable stunts in the name of cleansing. McKenna didn’t have a boat. And from my understanding she’s well respected by many business leaders in our state. I felt myself carrying that emotion with me into the real world.30,20.

artificial snow, At least three of Trump’s fellow Republicans in the U. Chelsea’s Eden Hazard. especially property belonging to the Gujjar community. and we as Americans will not be able to buy all those treasury bonds," said Dalio. and theres a gay James. she said. scientists, raises alarms.

066-ft. on Jan. read more